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Endocrine Abstracts

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ea0050oc1.5 | Early Career Oral Communications | SFEBES2017

An essential physiological role for MCT8 in bone

Leitch Victoria D. , Di Cosmo Caterina , Liao Xiao-Hui , O'Boy Sam , Galliford Thomas M. , Evans Holly , Croucher Peter I. , Boyde Alan , Dumitrescu Alexandra , Weiss Roy E. , Refetoff Samuel , Williams Graham R. , Duncan Bassett J.H.

T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter-8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compo...
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ea0050oc1.5 | Early Career Oral Communications | SFEBES2017

An essential physiological role for MCT8 in bone

Leitch Victoria D. , Di Cosmo Caterina , Liao Xiao-Hui , O'Boy Sam , Galliford Thomas M. , Evans Holly , Croucher Peter I. , Boyde Alan , Dumitrescu Alexandra , Weiss Roy E. , Refetoff Samuel , Williams Graham R. , Duncan Bassett J.H.

T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter-8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compo...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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